Xanthic Urolithiasis.
Pathophysiology Deficiency of the enzyme xanthine oxidoreductase, which catalyzes the hydroxylation of hypoxanthine to xanthine and xanthine to uric acid. This leads to increased urinary excretion of hypoxanthine and xanthine, which predisposes to xanthine stone formation. Serum and urine uric acid is significantly reduced. Two distinct forms of xanthinuria are recognized: type I (due to …









